Process for the preparation of Z-5-carboxymethylene-1,3-dioxolan-4-ones

US7507838B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• William A. Nugent · Wilmington, US
• Keming Zhu · Highland Park, US
• James H. Simpson · Fryeburg, US
• Edward J. Delaney · Princeton, US

Key dates

• Filing date: Aug 22, 2005
• Grant date: Mar 24, 2009
• Expiry date: Mar 27, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV integrase inhibitors employing the carboxymethylene-1,3-dioxolan-4-one inhibitor is also provided.