In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
US7510699B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 2004 |
| Grant date | Mar 31, 2009 |
| Priority date | — |
| Expiry date | Nov 2, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/0002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.In particular embodiments, the intensi…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.