Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists

US7511046B2 · kind B2 · utility

Assignee

• Aventis Hoklings Inc. · US

Inventors

• David M. Fink · Doylestown, US
• Brian S. Freed · Phillipsburg, US
• Nicholas J. Hrib · Somerville, US
• Raymond W. Kosley, Jr. · Bound Brook, US
• George E. Lee · Somerville, US
• Gregory H. Merriman · Somerville, US
• Barbara S. Rauckman · Flemington, US

Key dates

• Filing date: Jul 21, 2006
• Grant date: Mar 31, 2009
• Expiry date: Jul 21, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.