Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist

US7511064B2 · kind B2 · utility

Assignee

• Biofrontera Bioscience GmbH · DE

Inventors

• Hermann Lubbert · Burscheid, DE
• Christoph Ullmer · Fischingen, DE
• Emile Bellott · Beverly, US
• Mark Froimowitz · Newton, US
• Douglas J. Gordon · Somerville, US

Key dates

• Filing date: Apr 19, 2006
• Grant date: Mar 31, 2009
• Expiry date: Mar 20, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D421/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.