Method for preparing N-acetylglucosamine
US7511134B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 2005 |
| Grant date | Mar 31, 2009 |
| Priority date | — |
| Expiry date | Jun 7, 2027 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB32B2605/18
- WIPO fieldSurface technology, coating
- WIPO sectorChemistry
Abstract
A method for preparing n-acetylglucosamine starting from glucosamine base having a purity level of at least about 99 wt. % and a maximum halide content of about 0.01 wt %. The glucosamine base is slurried in a diluent comprising a C1-C4 straight or branched-chain alcohol, e.g., isopropyl alcohol, sec. butyl alcohol, tert. butyl alcohol, etc. Thereafter, an acylating agent, e.g., acetic anhydride, present in at least a stoichiometric amount, is slowly added to the slurry while maintaining the reaction mixture at a temperature below about 20° C. The n-acetylglucosamine prepared by the process of the invention will be quite pure, e.g., it will have a purity of at least 98%, as measured by HPLC, a melting point in the range of 196-205° C. and a specific rotation, measured at room temperature after standing in water for several hours, of [α]D=39-43°.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.