β-secretase enzyme compositions and methods
US7514408B1 · kind B1 · utility
6Cited by
40References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 4, 2000 |
| Grant date | Apr 7, 2009 |
| Priority date | — |
| Expiry date | Feb 2, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6896
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (APP and APPsw) are also disclosed. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.
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