VLA-4 antagonists

US7514409B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• William K. Hagmann · Westfield, US
• Linus S. Lin · Westfield, US
• Ping Liu · Shanghai, CN
• Richard A. Mumford · Red Bank, US
• Thomas S. Reger · Lansdale, US
• Nicholas D. Smith · San Diego, US
• Nicholas S. Stock · San Diego, US
• Jasmine Eleanor Zunic · San Diego, US

Key dates

• Filing date: Mar 7, 2005
• Grant date: Apr 7, 2009
• Expiry date: Oct 8, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.