Inhibitors against complex II of electron transport system
US7514455B2 · kind B2 · utility
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Key dates
| Filing date | Jun 10, 2002 |
| Grant date | Apr 7, 2009 |
| Priority date | — |
| Expiry date | Apr 4, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I]wherein R is alkyl or alkenyl optionally having substituent containing halogen, or its tautomer 2-pyridone derivative represented by the general formula [II]wherein R is alkyl or alkenyl optionally having substituent containing halogen, or salt thereof as an active ingredient. The compound inhibits the complex II strongly with nM order activity. Consequently, 2-pyridinol derivative or its tautomer, 2-pyridone derivative, are useful as the complex II inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.