Polynucleotides encoding immunoadhesins comprising a glycoprotein VI domain

US7514543B2 · kind B2 · utility

Assignee

• Trigen GmbH · GB

Inventors

• Steffen Massberg · Birkenfeld, DE
• Meinrad Gawaz · Bingen, DE
• Andreas Bültmann · Planegg, DE
• Götz Münch · Birkenfeld, DE
• Martin Ungerer · Martinsried, DE
• Mario Peluso · Penzberg, DE

Key dates

• Filing date: Jun 5, 2003
• Grant date: Apr 7, 2009
• Expiry date: May 10, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a fusion protein comprising (a) the extracellular domain of glycoprotein VI or a variant thereof that is functional for binding to collagen and (b) the Fc domain of an immunoglobulin or a function-conservative part thereof, characterised by a polypeptide chain having an amino acid sequence as shown in FIG. 7 and whereby the fusion protein is obtainable by a process which provides the fusion protein in the form of a specific dimer.