Thiazole compounds and methods of use

US7514566B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Qingping Zeng · Thousand Oaks, US
• John Gordon Allen · Newbury Park, US
• Matthew P. Bourbeau · Calabasas, US
• Celia Dominguez · Los Angeles, US
• Christopher H. Fotsch · Thousand Oaks, US
• Nianhe Han · Newbury Park, US
• Fang-Tsao Hong · Thousand Oaks, US
• Xin Huang · Brookline, US
• Matthew Lee · Calabasas, US
• Aiwen Li · Westlake Village, US
• Qingyian Liu · Camarillo, US
• James T. Rider · Calabasas, US
• Seifu Tadesse · Simi Valley, US
• Andrew Tasker · Simi Valley, US
• Vellarkad N. Viswanadhan · Nagamangala, IN
• Xianghong Wang · Dublin, US
• Kurt E. Weiler · Thousand Oaks, US
• George E. Wohlhieter · San Fernando, US
• Guomin Yao · Mililani, US
• Chester Chenguang Yuan · Newbury Park, US

Key dates

• Filing date: Jan 11, 2007
• Grant date: Apr 7, 2009
• Expiry date: Jan 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein.The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.