Patent · US Expired

Bioconjugates comprising sulfated polysaccharides and their uses

US7517856B2 · kind B2 · utility

14Cited by

2References

23Claims

0Family size

Assignee

BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY · IL

Inventors

Smadar Cohen · Beer Sheva, IL
Inbar Freeman · Beer Sheva, IL

Key dates

Filing date	Oct 11, 2005
Grant date	Apr 14, 2009
Priority date	—
Expiry date	Feb 8, 2026

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S977/773
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides bioconjugates comprising a sulfated polysaccharide such as alginate sulfate and hyaluronan sulfate and at least one bioactive polypeptide capable of binding a sulfate group of said sulfated polysaccharide. The bioactive polypeptide can be a heparin-binding polypeptide and/or a positively-charged polypeptide. Also, provided are delivery systems and methods for sustained release of said bioactive polypeptide(s) using said bioconjugates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.