Bichalcophenes and their prodrugs as antiprotozoal agents
US7517893B2 · kind B2 · utility
10Cited by
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33Claims
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Key dates
| Filing date | May 16, 2006 |
| Grant date | Apr 14, 2009 |
| Priority date | — |
| Expiry date | Sep 11, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
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