Flow method and apparatus for screening chemicals using micro x-ray fluorescence

US7519145B2 · kind B2 · utility

Assignee

• LOS ALAMOS NATIONAL SECURITY, LLC · US

Inventors

• Benjamin P. Warner · Los Alamos, US
• George Havrilla · Los Alamos, US
• Thomasin Miller · Los Alamos, US
• Cris Lewis · Los Alamos, US
• Cynthia Mahan · Los Alamos, US
• Cyndi Wells · Los Alamos, US

Key dates

• Filing date: May 31, 2006
• Grant date: Apr 14, 2009
• Expiry date: Sep 10, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2223/076
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow-separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.