Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells

US7521047B2 · kind B2 · utility

Assignees

• GPC Biotech AG · US
• MORPHOSYS AG · DE

Inventors

• Zoltan Nagy · Wolfratshausen, DE
• Christoph Brunner · Bad Heilbrunn, DE
• Michael Tesar · Heidelberg, DE
• Elisabeth Thomassen-Wolf · Birkenfeld, DE
• Robert Rauchenberger · Martinsried, DE

Key dates

• Filing date: Nov 15, 2001
• Grant date: Apr 21, 2009
• Expiry date: Apr 20, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.