Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands

US7521445B2 · kind B2 · utility

Assignee

• Aventis Pharmaceuticals Inc. · US

Inventors

• James Hendrix · Fryeburg, US
• Horst Hemmerle · Lorsch, DE
• Matthias Urmann · Eschborn, DE
• Gregory M. Shutske · Somerville, US
• Joseph T. Strupczewski · Flemington, US
• Kenneth J. Bordeau · Myerstown, US
• John G. Jurcak · Somerville, US
• Thaddeus Nieduzak · Bound Brook, US
• Sharon Jackson · Whitehouse Station, US
• Paul Angell · Carlsbad, US
• James P Carey · Cincinnati, US
• George E. Lee · Somerville, US
• David Fink · Lebanon, US
• Jean-Francois Sabuco · Paris, FR
• Yulin Chiang · Clay, US
• Nicola Collar · Jersey City, US

Key dates

• Filing date: Mar 5, 2007
• Grant date: Apr 21, 2009
• Expiry date: Mar 5, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D3 receptors.