N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate

US7521456B2 · kind B2 · utility

Assignee

• OSI Pharmaceuticals, LLC · US

Inventors

• Douglas J. M. Allen · Indianapolis, US
• Timothy Norris · Gales Ferry, US
• Jeffrey W. Raggon · Uncasville, US
• Dinos P. Santafianos · Manchester, US
• Ravi M. Shanker · Groton, US

Key dates

• Filing date: Nov 17, 2003
• Grant date: Apr 21, 2009
• Expiry date: Dec 12, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/94
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to the anhydrous and hydrate forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate. The invention also relates to pharmaceutical compositions containing N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate and to methods of treating hyperproliferative disorders, such as cancer, by administering N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate.