Inhibitors of protein tyrosine phosphatase 1B

US7521473B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Jinbo Lee · Andover, US
• Zhao-Kui Wan · Lexington, US
• Douglas Wilson · Cambridge, US
• Bruce Follows · Littleton, US
• Steven J. Kirincich · Concord, US
• Michael J. Smith · Somerville, US
• Jun-Jun Wu · Arlington, US
• Kenneth W. Foreman · Syosset, US
• David V. Erbe · Arlington, US
• Yan Zhang · Fort Washington, US
• Weixin Xu · Acton, US
• Steve Y. Tam · Wellesley, US

Key dates

• Filing date: Feb 23, 2005
• Grant date: Apr 21, 2009
• Expiry date: Oct 11, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.