Process for preparation of substituted amino alcohols
US7521552B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Dec 8, 2004 |
| Grant date | Apr 21, 2009 |
| Priority date | — |
| Expiry date | Jan 19, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C213/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a process for the preparation of substituted amino alcohols HO—(CH2)n—NR1R2 from haloalcohols HO—(CH2)n—X, where X is Cl, Br or I, by reaction with an amine HNR1R2, in water as solvent at a temperature range of about 20° C. to about 90° C. optionally in the presence of a catalytic amount of an iodide source metal iodides. The haloalcohols are useful in the preparation of 6-[(substituted)phenyl]-triazolopyrimidine compounds which are useful in the treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.