Patent · US Active

Non-cytotoxic synthetic analogues of (1E, 6E)-1, 7-Bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-Dione and therapeutic applications thereof in cystic fibrosis

US7521580B1 · kind B1 · utility

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8Claims

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Assignee

SAMI LABS LIMITED · IN

Inventors

Muhammed Majeed · Plainsboro, US
Rajinder Kumar Bammi · Bengaluru, IN
Natarajan Sankaran · Kanchinakote, IN
Subbalakshmi Prakash · Piscataway, US
Kalyanam Nagabhushanam · Plainsboro, US
Samuel Manoharan Thomas · Bengaluru, IN
Susmitha Anand · Bengaluru, IN
Geetha Kanhangad-Gangadharan · Bengaluru, IN

Key dates

Filing date	Feb 18, 2008
Grant date	Apr 21, 2009
Priority date	—
Expiry date	Feb 18, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C45/74
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl−) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.