Molecular interferometric imaging process and apparatus
US7522282B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 4, 2007 |
| Grant date | Apr 21, 2009 |
| Priority date | — |
| Expiry date | Jul 24, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/253
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A molecular interferometric imaging system for detecting an analyte in a sample, that includes an illumination source providing a beam of radiation; a pixel array for detecting radiation in an image plane; a biolayer designed to react to the analyte when it comes in contact with the sample; a substrate designed to convert phase modulation into intensity modulation which can be detected and imaged directly by the pixel array, the biolayer being on the substrate; a reference surface; an image switching means for switching between a first position for collecting a sample image of the biolayer, and a second position for collecting a reference image of the reference surface; and a processing means for producing a composite image using the sample image and the reference image for illumination normalization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.