Methods for controlling one or more parameters of a flow cytometer type measurement system
US7523637B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 29, 2007 |
| Grant date | Apr 28, 2009 |
| Priority date | — |
| Expiry date | Nov 29, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/12746
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.