Functional assays that use the T1R1 receptor to screen for T1R1-associated taste modulators
US7524637B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 1, 2003 |
| Grant date | Apr 28, 2009 |
| Priority date | — |
| Expiry date | Jul 11, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Functional assays that use the T1R1 receptor to screen for taste modulatory compounds are provided. These assays include cell-based assays and high throughput compound assays to identify compounds that activate T1R1 or modulate T1R1 receptor activation by compound. Preferred functional assays detect the effect of a putative taste modulatory compound on cell voltage or intracellular calcium in a cell that expresses a T1R1 polypetide, preferably in association with a G protein, e.g. G{acute over (α)}15. Compounds identified using these assays have potential application as flavor enhancer and modulators in foods and beverage for human or animal consumption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.