Azaindazole compounds and methods of use

US7524845B2 · kind B2 · utility

Assignee

• CHEMOCENTRYX, INC. · US

Inventors

• Penglie Zhang · Foster City, US
• Andrew Pennell · San Francisco, US
• John J. Wright · Evansville, US
• Wei Chen · Fremont, US
• Manmohan Reddy Leleti · Sunnyvale, US
• Yandong Li · San Jose, US
• Lianfa Li · Palo Alto, US
• Yuan Xu · Singapore, SG

Key dates

• Filing date: Jun 22, 2006
• Grant date: Apr 28, 2009
• Expiry date: Mar 2, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.