Fluorescent probe
US7524974B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 7, 2003 |
| Grant date | Apr 28, 2009 |
| Priority date | — |
| Expiry date | Sep 29, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N31/22
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A fluorescent probe which is represented by the following formula (I):(wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or the like; R3 represents a monovalent substituent; R4 and R5 represent hydrogen atom or a halogen atom; R6 represents hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, provided that a combination of R1, R2, and R3 provides (1) substantially high electron density of the benzene ring to which said groups bind, so that the compound represented by the formula (I) is substantially no fluorescent before the trapping of proton, or the like, and (2) substantially reduced electron density of the benzene ring to which said groups bind, so that a compound after the trapping, which is derived from the compound represented by the formula (I) is substantially highly fluorescent after the trapping of proton or the like). A fluorescent probe having an excellent fluorescence property is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.