Expression profile algorithm and test for cancer prognosis

US7526387B2 · kind B2 · utility

Assignees

• Genomic Health, Inc. · US
• NSABP Foundation, Inc. · US

Inventors

• Joffre B. Baker · Montara, US
• John L. Bryant · Washington, US
• Soonmyung Paik · Pittsburgh, US
• Steven Shak · Burlingame, US

Key dates

• Filing date: Jun 30, 2004
• Grant date: Apr 28, 2009
• Expiry date: Sep 17, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs (mRNAs). These mRNA levels are inserted into a polynomial formula (algorithm) that yields a numerical recurrence score, which indicates recurrence risk.