Patent · US Active

Histone H2A peptide derivatives and uses thereof

US7528227B2 · kind B2 · utility

1Cited by

9References

10Claims

0Family size

Assignee

YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventor

Uri Wormser · Jerusalem, IL

Key dates

Filing date	Sep 25, 2006
Grant date	May 5, 2009
Priority date	—
Expiry date	Sep 25, 2026

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury induced by noxious stimuli when administered to animals. Pharmaceutical compositions and methods of using these peptides are also disclosed. The pharmaceutical compositions according to the invention are useful for treating and protecting against inflammatory diseases, autoimmune diseases, for treating and protecting against tissue damage, for inhibiting metalloproteinase activity, and for treating and protecting against diseases associated with the breakdown of extracellular matrix or connective tissues.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.