Cyclic malonamides as inhibitors of aβ protein production
US7528249B2 · kind B2 · utility
13Cited by
59References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 19, 2008 |
| Grant date | May 5, 2009 |
| Priority date | — |
| Expiry date | Jun 19, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to novel cyclic malonamides having the formula (I):to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.