Method for enantioselective preparation of sulphoxide derivatives
US7528251B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Oct 5, 2005 |
| Grant date | May 5, 2009 |
| Priority date | — |
| Expiry date | Oct 5, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns enantioselective preparation of sulphoxide derivatives or their salts. The method consist in performing an enantioselective oxidation of a sulphur of general formula (I) A —CH2—SB, wherein: A is a diversely substituted pyridinyl ring and B is a heterocyclic radical comprising an imidazo-pyridinyl ring, using an oxidizing agent in the presence of a titanium (IV)-based catalyst and a chiral ligand consisting of a cyclic beta or gamma-amino-alcohol, in an organic solvent, followed, if required, by salt formation with a base. The invention is useful for preparing sulphoxides useful in therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.