Process for the preparation of simvastatin
US7528265B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Dec 26, 2002 |
| Grant date | May 5, 2009 |
| Priority date | — |
| Expiry date | Jan 15, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecting the hydroxy group on the lactone ring; and acylating the resulting compound with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide in the presence of an acylation catalyst in an organic solvent, followed by removing the silyl protecting group on the lactone ring to obtain simvastatin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.