Methods for identifying modified tumor necrosis factor-alpha converting enzyme inhibitors
US7529628B2 · kind B2 · utility
1Cited by
5References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 18, 2006 |
| Grant date | May 5, 2009 |
| Priority date | — |
| Expiry date | Oct 18, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In addition, the present invention discloses methods of using the proteins, crystals and/or three-dimensional structures obtained to identify compounds that can modulate the enzymatic activity of TACE.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.