On-chip temperature controlled liquid chromatography methods and devices
US7530259B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 2005 |
| Grant date | May 12, 2009 |
| Priority date | — |
| Expiry date | Feb 17, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2035/00108
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.