IL-1β binding antibodies and fragments thereof

US7531166B2 · kind B2 · utility

Assignee

• XOMA TECHNOLOGY LTD. · US

Inventors

• Linda Masat · Walnut Creek, US
• Mary Haak-Frendscho · Madison, US
• Gang Chen · Sammamish, US
• Arnold Horwitz · San Leandro, US
• Marina Roell · Concord, US

Key dates

• Filing date: Jun 21, 2006
• Grant date: May 12, 2009
• Expiry date: Mar 1, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.