Modified cytochrome p450 monooxygenases

US7531335B1 · kind B1 · utility

Assignee

• BASF SE

Inventors

• Bernhard Hauer · Neheim, DE
• Juergen Pleiss · Asperg, DE
• Ulrich Schwaneberg · Waiblingen, DE
• Jutta Schmitt · Stuttgart, DE
• Markus Fischer · Ludwigsburg, DE
• Rolf Schmid · Gelterkinden, CH
• Qing-shan Li · Kyoto, JP

Key dates

• Filing date: Jul 27, 2000
• Grant date: May 12, 2009
• Expiry date: Jul 27, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/90245
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.