Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same

US7531338B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• The Board of Trustees of the University of Illinois · US

Inventors

• Jian Liu · Los Angeles, US
• Guoqing Xia · Hamburg, DE
• Jinghua Chen · Schaumburg, US
• Michael B. Duncan · Chapel Hill, US
• Deepak Shukla · Oshkosh, US
• Vaibhav Tiwari · Chicago, US
• Anders Malmström · Lund, SE

Key dates

• Filing date: Jul 7, 2003
• Grant date: May 12, 2009
• Expiry date: Jul 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/028
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.