Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7531341B1 · kind B1 · utility
59Cited by
17References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 12, 2006 |
| Grant date | May 12, 2009 |
| Priority date | — |
| Expiry date | Aug 15, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to phenylalanine ammonia lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologically active fragments, mutants, variants and analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic and industrial purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.