Non self-inactivating, expression targeted retroviral vectors
US7531353B1 · kind B1 · utility
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65Claims
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Key dates
| Filing date | Feb 28, 1997 |
| Grant date | May 12, 2009 |
| Priority date | — |
| Expiry date | Feb 28, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/13043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5′LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding sequences; and a 3′LTR region comprising a completely or partially deleted U3 region wherein said deleted U3 region is replaced by a polylinker sequence, followed by the R and U5 region. The retroviral vector undergoes promoter conversion and is useful as a gene transfer vehicle for targeted gene therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.