Spiro-substituted pyrrolo[2,3-D]pyrimidines as cathepsin inhibitors
US7531546B2 · kind B2 · utility
4Cited by
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8Claims
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Key dates
| Filing date | Feb 27, 2004 |
| Grant date | May 12, 2009 |
| Priority date | — |
| Expiry date | Jun 12, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof formula (I) wherein the symbols have the meaning as defined in the description. Said compounds are inhibitors of cathepsin K and/or cathepsin S and are useful for the treatment of diseases and medical conditions in which cathepsin K and/or cathepsin S is implicated, e.g. various disorders including neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, multiple sclerosis and tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.