Molecular mimetics of meningococcal B epitopes which elicit functionally active antibodies

US7534444B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• Dan M. Granoff · Berkeley, US
• Gregory R. Moe · Alameda, US
• Rino Rappuoli · Siena, IT

Key dates

• Filing date: Apr 11, 2002
• Grant date: May 19, 2009
• Expiry date: Apr 11, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.