Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7534595B2 · kind B2 · utility
56Cited by
17References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 25, 2007 |
| Grant date | May 19, 2009 |
| Priority date | — |
| Expiry date | Aug 16, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to phenylalanine ammonia-lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologically active fragments, mutants, variants and analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic and industrial purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.