Fusion polypeptides capable of activating receptors
US7534604B2 · kind B2 · utility
35Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 2005 |
| Grant date | May 19, 2009 |
| Priority date | — |
| Expiry date | Mar 22, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different ScFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.