Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds

US7534787B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Klaus Bornemann · Ingelheim am Rhein, DE
• Guenter Trummlitz · Warthausen, DE
• Bernd Beck · Mengerskirchen, DE
• Frank Sams-Dodd · Biberach, DE
• Dagmar Kugler · Schemmerhofen, DE
• Klaus Klinder · Oggelshausen, DE
• Cornelia Dorner-Ciossek · Ingelheim am Rhein, DE
• Marcus Kostka · Biberach, DE

Key dates

• Filing date: Jan 17, 2008
• Grant date: May 19, 2009
• Expiry date: Jan 17, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D279/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ibwherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.