Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
US7537923B2 · kind B2 · utility
35Cited by
17References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 22, 2008 |
| Grant date | May 26, 2009 |
| Priority date | — |
| Expiry date | Apr 22, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.