Biomarker detection in circulating cells
US7537938B2 · kind B2 · utility
28Cited by
106References
11Claims
0Family size
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Key dates
| Filing date | Jan 26, 2004 |
| Grant date | May 26, 2009 |
| Priority date | — |
| Expiry date | Apr 13, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6845
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method is provided for detecting biomarkers in rare circulating cells by forming an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having releasable molecular tags. Preferably, biomarkers comprising one or more protein-protein complexes are detected in circulating cancer cells metastasized from a solid tumor. In the presence of biomarkers, the molecular tags of the binding compounds are released and separated from the assay mixture for detection and/or quantification.
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