Oxazinan-2-one derivatives useful as PR modulators

US7538107B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Thomas J. Commons · Wayne, US
• Andrew Fensome · Wayne, US
• Gavin David Heffernan · Florence, US
• Casey Cameron McComas · Phoenixville, US
• Richard Page Woodworth, Jr. · North Wales, US
• Michael Byron Webb · Douglassville, US
• Michael Anthony Marella · Philadelphia, US
• Edward George Melenski · Woodlyn, US
• Ronald Charles Bernotas · Royersford, US

Key dates

• Filing date: Aug 13, 2007
• Grant date: May 26, 2009
• Expiry date: Aug 13, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the following structure are described:wherein R1-R6, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.