Method of screening groups of radioactive molecules and applications thereof
US7541157B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 28, 2003 |
| Grant date | Jun 2, 2009 |
| Priority date | — |
| Expiry date | May 28, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5082
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.