Activation and expansion of cells

US7541184B2 · kind B2 · utility

Assignee

• Invitrogen Corporation · US

Inventors

• Ronald J. Berenson · Mercer Island, US
• Che-Leung Law · Bothell, US
• Mark Bonyhadi · Issaquah, US
• Narinder Saund · Seattle, US
• Stewart Craig · Issaquah, US
• Alan Hardwick · Seattle, US
• Dale Kalamasz · Redmond, US
• David McMillen · Seattle, US
• Harjinder Chana · Issaquah, US

Key dates

• Filing date: Jan 20, 2004
• Grant date: Jun 2, 2009
• Expiry date: Jan 20, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.