Thrombopoietin proteins with improved properties
US7541439B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Jun 25, 2004 |
| Grant date | Jun 2, 2009 |
| Priority date | — |
| Expiry date | Jul 7, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molecules, preferably fusion proteins comprising immunoglobulin constant regions and modified human TPO, with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.