Tet repressor-based transcriptional regulatory proteins

US7541446B2 · kind B2 · utility

Assignee

• TET Systems GmbH & Co. KG · DE

Inventors

• Wolfgang Hillen · Erlangen, DE
• Hermann Bujard · Heidelberg, DE
• Stefanie Urlinger · Munich, DE

Key dates

• Filing date: Jun 5, 2003
• Grant date: Jun 2, 2009
• Expiry date: May 19, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/006
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides a panel of transcriptional activator fusion proteins which comprises both tetracycline controlled transactivator proteins and reverse tetracycline transactivator proteins. These transactivators have novel phenotypes such as altered basal transcriptional activity in the absence of doxycycline, altered induced transcriptional activity in the presence of doxycycline, or differential induction by tetracycline and analogs of tetracycline.