Sulfur-containing naphthalimide derivatives

US7541463B2 · kind B2 · utility

Assignees

• East China University of Science and Technology · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• Dalian University of Technology · CN

Inventors

• Xuhong Qian · Shanghai, CN
• Yonggang Li · Shanghai, CN
• Yufang Xu · Shanghai, CN
• Jian Ding · Shanghai, CN
• Liping Lin · Xiamen, CN
• Zehong Miao · Shanghai, CN
• Hong Zhu · Shanghai, CN
• Baoyuan Qu · Shanghai, CN

Key dates

• Filing date: Oct 31, 2005
• Grant date: Jun 2, 2009
• Expiry date: Jun 23, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B69/109
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.