Patent · US Active

Synthesis of himbacine analogs

US7541471B2 · kind B2 · utility

4Cited by

5References

23Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Tiruvettipuram K. Thiruvengadam · Kendall Park, US
Tao Wang · Farmington, US
Jing Liao · Edison, US
John S. Chiu · Parsippany, US
David Jieh-Shyh Tsai · Hackettstown, US
Hong-Chang Lee · Livingston, US
Wenxue Wu · Princeton Junction, US
Xiaoyong Fu · Edison, US

Key dates

Filing date	Jan 12, 2006
Grant date	Jun 2, 2009
Priority date	—
Expiry date	Mar 31, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.An example of a step in the synthesis of such a himbacine analog is as follows:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.